Allopurinol is a generic drug sold under a variety of brand names. One of the major reasons is that cyclosporine is a medication that is generally used for a very specialized purpose. The drug nutrient interactions table may not include every possible interaction. The drugs that it interacts with are generally not very commonly used, apart from amoxicillin, which is a common antibiotic. This table lists common drugs that can affect nutrition status.
Although it is well known and identifi ed that drug drug interactions exist, the recognition of importance of food and drug interactions to practice has been growing much slower. We would like to show you a description here but the site wont allow us. Allopurinol may also be used for purposes not listed in this medication guide. Drug induced vitamin d deficiency can produce hypocalcemia and elevate parathyroid hormone. Uric acid buildup can lead to gout or kidney stones.
Allopurinol is a prescription medication that is used for different conditions. Zyloprim allopurinol dose, indications, adverse effects. Allopurinol, a structural analogue of hypoxanthine, is used primarily in the treatment of hyperuricaemia and gout. Drug interactions can be caused by prescription and overthecounter medications, herbal products or vitamins, foods, diseases, and genetics family history. Allopurinol and cyclosporine interaction med ed 101. Improve your health and avoid side effects when using common medications and natural supplements together book online at best prices in india on. Started in 1995, this collection now contains 6767 interlinked topic pages divided into a tree of 31 specialty books and 732 chapters.
Allopurinol is sold as an injection for intravenous use and as a tablet. Handbook of drugnutrient interactions, second edition is a comprehensive uptodate text for the total management of patients on drug andor nutrition therapy but also an insight into the recent developments in drug nutrition interactions which will act as a reliable reference for clinicians and students for many years to come. Table 1 summarizes several possible interactions of drugs with. Alkawas fh, seeff lb, berendson ra, zimmerman hj, ishak kg allopurinol hepatotoxicity. Allopurinol complete drug information, side effects and. Allopurinol, sold under the brand name zyloprim among others, is a medication used to decrease high blood uric acid levels. For example, do not take vitamin c supplements or consume excessive amounts of vitamin c, as this can interact with allopurinol and lead to kidney stone formation. Buy az guide to drugherbvitamin interactions revised and. Allopurinol is now available all over the world, as it is now a generic.
Severe interactions these medications are not usually taken together. For example, tyramine, a component of cheese and a potent vasoconstrictor, can cause hypertensive crisis in some patients who take monoamine oxidase inhibitors and eat cheese. Drug interactions are reported among people who take allopurinol and marijuana together. It is taken by mouth or injected into a vein common side effects when used by mouth include itchiness and rash. The monoamine oxidase inhibitortyramine interaction. Allopurinol is a xanthine oxidase inhibitor and a widely used medication for gout.
Improve your health and avoid side effects when using common. For more interactions complete data for allopurinol 15 total, please visit the hsdb record page. A formula diet was administered with the allopurinol throughout the 24day study, while hydrochlorothiazide was added during days 1121. Drug interactions of medications commonly used in diabetes. Examine the name allopurinol and you can see the word purine in the middle of the name. Drug interactions checker check your brand and generic.
Aug 14, 2019 allopurinol is known chemically as 1,5dihydro4 h pyrazolo 3,4 d pyrimidin4one. Read az guide to drug herbvitamin interactions revised and expanded 2nd edition. Allopurinol c5h4n4o cid 5401907 structure, chemical names. Warfarin is one of the top three drugs alongside insulin and digoxin that are most commonly associated with severe drug related complications. Handbook of drugnutrient interactions, 2nd edition nutrition and. Each of these interactions may lead to many complications. Allopurinol drug information kaiser permanente washington. Allopurinol works by reducing the amount of uric acid made by the body. Ace inhibitors and diuretics may potentially cause drug interactions with allopurinol. This book is distributed under the terms of the creative commons attribution 4. This definition applies to interactions of drugs with other drugs drug drug interactions, as well as drugs with food drug food interactions and other substances.
Allopurinol is a xanthine oxidase inhibitor used to prevent gout and to lower blood levels of uric acid in certain people taking drugs for cancer. Allopurinol, a xanthine oxidase inhibitor, is a uratelowering medication. It is specifically used to prevent gout, prevent specific types of kidney stones and for the high uric acid levels that can occur with chemotherapy. It has been reported that allopurinol prolongs the halflife of the anticoagulant, dicumarol.
When medications such as ace inhibitors, antacids, and diuretics are taken with allopurinol, it can increase your risk of developing serious side effects. Allopurinol interacts with several drugs in a few different ways. Feb 28, 2006 the az guide to drugherbvitamin interactions is an essential resource to understanding the interactions that may affect your health. In patients receiving mercaptopurine or imuran azathioprine, the concomitant administration of 300 to 600 mg of zyloprim allopurinol per day will require a reduction in dose to approximately one third to one fourth of the usual dose of mercaptopurine or azathioprine. Allopurinol potentially increases the risk of haematological toxicity when given with azathioprine. Allopurinol and cannabis drug interactions ehealthme. This page also lists other drugs that may interact with allopurinol. Allopurinol is a xanthine oxidase inhibitor used to prevent goutand to lower blood levels of uric acid in certain people taking drugs for cancer. The following medications can interact with allopurinol and alter its effectiveness. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Potential drug interactions and relative contraindications.
Analysis of potential interactions between warfarin and. Allopurinol is cleared essentially by glomerular filtration, but oxypurinol is reabsorbed in the kidney tubules in a manner similar to the reabsorption of uric acid. The allopurinol and cyclosporine interaction is one that isnt as common as other interactions. Drug nutrient interactions involve changes to a drug caused by a nutrient, or changes to a nutrient as a result of the drug. A drug interaction can be defined as an interaction between a drug and another substance that prevents the drug from performing as expected. Allopurinol can also alter the amounts of certain medications in your blood. Allopurinol inhibits an enzyme that is necessary to form uric acid, a substance present in abnormally large amounts in the blood of persons with. Handbook of drugnutrient interactions springerlink. Use with oral hypoglycemicagents and warfarinq effects of these drugs. The clinical basis of this drug interaction has not been established but should be noted when allopurinol is given to patients already on dicumarol therapy. Lopurin, zyloprim allopurinol uses, side effects, dosage. Az guide to drugherbvitamin interactions revised and. In this lesson, we will learn how food and other drugs may interact with allopurinol and when it should not be used. Food and drug administration or any other regulatory.
Allopurinol and 6mercaptopurine 6mp drug interaction. Allopurinol uses, dosage, side effects, composition. Allopurinol and marijuana drug interactions ehealthme. Allopurinol tablets usp, 100 mg and 300 mg contain the following inactive ingredients. Drug interactions with allopurinol arthritis home page. The interaction is considered significant from a clinical.
Common drug nutrient interactions anticoagulants anticoagulants eg, warfarin help reduce the formation of blood clots. Drug interactions are reported among people who take allopurinol and vitamin d together. Captopril is predicted to increase the risk of hypersensitivity and haematological reactions when given with allopurinol. Drug drug interactions allopurinol is a medication used for gout and hyperuricemia associated with cancer treatment that has a potentially devastating interaction with 6mercaptopurine 6mp. Of note, of note, watching your intake of animalbased proteins can help reduce the risk of additional gout flareups.
Allopurinol interactions bnf content published by nice. This drugfooddrug herb interaction guide should not be used as a substitute for publications issued by a manufacturer or distributor of food, herbs or medications, publications issued by the u. The interaction of allopurinol 300 mgday and hydrochlorothiazide 50 mgday was studied in seven healthy male volunteers during prolonged coadministration of the two drugs using defined dietary conditions. Discounts are available exclusively through participating pharmacies. Learn about allopurinol from patients first hand experiences and trusted online health resources, including dosage, side effects and interactions. Get facts about the types of drug interactions, what substances or other things that may interact with drugs such as otc drug and prescription drugs, vitamins, food s grapefruit, and laboratory tests. Drug nutrient interactions table of common drugs and medications. Drugs and intrinsic factor n allopurinol n colestyramine n colchicine n metformin n methyldopa n neomycin. Nutritional deficiencies can affect drug absorption and metabolism. Bendroflumethiazide is predicted to increase the risk of hypersensitivity reactions when given with allopurinol. Use with thiazidediureticsor aceinhibitorsqrisk of hy. We look into the drug interactions by gender and age.
These medications may interact and cause very harmful effects. There are many drug and food interactions associated with allopurinol. Allopurinol was initially approved by the food and drug administration, or fda, in 1966, and was sold under the trade name of zyloprim. Mar 31, 2012 warfarin is one of the top three drugs alongside insulin and digoxin that are most commonly associated with severe drug related complications. Drug interactions with allopurinol certain medications may cause potentially serious drug interactions with allopurinol. Pharmacokinetics and pharmacodynamics of allopurinol in.
If the client is taking a drug or medication that isnt on this list, check the food medications interactions book for possible side effects. Drug interactions although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. A 58 year old male is receiving chronic cyclosporine. Allopurinol zyloprim, aloprim is a drug used to treat gout. Consequently, the action of a drug may also be affected by a micronutrient. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. Within 4872 hours, approximately 12% of the drug is excreted as allopurinol, 76% is excreted as oxypurinol, and the remaining dose is excreted as riboside conjugates in the urine. Common side effects of allopurinol include nausea, vomiting, diarrhea, dizziness, and joint pain. Although drugnutrient interactions can produce therapeutic failure, adverse drug reactions, and altered nutritional status, many clinicians do not. Nutrientdrug interactions nutritional disorders merck. Vitamin k is essential for the production of clotting factors that help the blood clot and thus prevent bleeding. It can also reduce corresponding vitamin d metabolites.
Allopurinol reduces the production of uric acid in your body. Know allopurinol uses, side effects, dosage, contraindications, benefit, interactions, purpose, drug interactions. Certain medications may cause potentially serious drug interactions with allopurinol. Allopurinol oral zyloprim side effects, medical uses, and. Isoniazid drug can lower levels of both activated vitamin d and calcium levels. One wellknown drugmicronutrient interaction is a decrease in the. Buy az guide to drug herbvitamin interactions revised and expanded 2nd edition.
Use with mercaptopurine and azathioprineqbone marrow depressant propertiesdoses of these drugs should bep. Allopurinol is predicted to decrease the effects of capecitabine. Allopurinol is an antigout agent which is used to prevent gout attacks by reducing the uric acid production. Az guide to drugherbvitamin interactions revised and expanded. Find out how to protect yourself from potential drug interactions. Does allopurinol interact with other medications or foods. Cyclosporine is a calcineurin inhibitor that is primarily used in organ transplantation. One wellknown drug micronutrient interaction is a decrease in. It should be started at low doses and increase gradually. Potential serious interactions with the use of saliscylates, loop diuretics, phenylbutazamines and alcohol and potential for drug interactions with warfarin coumadin.
Use cautiously with patients with liver disease, renal failure, and women who are pregnant or lactating. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is. A uric acid buildup can lead to gout or kidney stones. Pge2, dicarboxylates, and drugs such as allopurinol, bumetanide, 5fluorouracil. The az guide to drugherbvitamin interactions is an essential resource to understanding the interactions that may affect your health. Get facts about the types of drug interactions, what substances or other things that may interact with drugs such as otc drug and prescription drugs, vitamins, foods grapefruit, and laboratory tests. The drugnutrient interactions table may not include every possible interaction. Anticoagulants exert their effect by blocking vitamin k in the production of these clotting factors.
As this emedtv page explains, these interactions can potentially lead to serious complications. Allopurinol and vitamin d drug interactions ehealthme. This medication is known by a wide variety of names, although it is still commonly referred to as zyloprim or allopurinol. Drug interactions are reported among people who take allopurinol and cannabis together. Allopurinol can interact with ingredients in some foods and medications. Allopurinol zyloprim side effects, dosage, interactions. The true incidence of drug interactions is unknown because many are not reported, do not result in significant harm to patients, or do not require admission to a hospital. Handbook of drugnutrient interactions nutrition and health.
It is not recommended in the patients with the known history of allergy. Allopurinol is a xanthine oxidase inhibitor used to prevent gout and to lower. Allopurinol was marketed at the time by burroughswellcome. Allopurinol can increase iron storage in liver, vitamin b12 deficiency. This study is created by ehealthme based on reports of 4,091 people who take allopurinol and vitamin d from the food and drug administration fda, and is updated regularly. Antineoplastic drugs an overview sciencedirect topics. He has authored five books and oversees the healthnotes, inc. Although drug interactions may enhance or diminish the antitumor effects and result in improvement or treatment failure, drug interactions may also increase or decrease the sideeffect profile of the antineoplastic drug. That which results from a physical, chemical, physiological or pathophysiological relationship between a drug and a nutrient. This study is created by ehealthme based on reports of 26 people who take allopurinol and marijuana from the food and drug administration fda, and is updated regularly. Allopurinol is used to treat gout or kidney stones, and to decrease levels of uric acid in people who are receiving cancer treatment. Elevated levels of blood uric acid levels can also cause kidney disease and stones.
In these cases, your doctor may want to change the dose, or other precautions may be necessary. Food medication interactions 19th edition zaneta m pronsky ms rd ldn fada, dean elbe bsc pharm bcpp pharm d, laura finn bcgp fascp, william roberts md phd, keith ayoob edd rd fada, sol epstein md frcp facp on. Allopurinol gout medication no known or reported drug nutrient interactions in the scientific literature. Drug interactions can be defined as the modification of the safety and efficacy profile of a medication following the coadministration of drugs, environmental pollutants, ingredients or additives present in the diet see 5.
Each white to off white tablet contains 100 mg or 300 mg of allopurinol and the inactive ingredients lactose, crospovidone, magnesium stearate, maize starch, and povidone. You should not use allopurinol if you have ever had a serious allergic reaction to it. Allopurinol has been marketed in the united states since august 19, 1966, when it was first approved by fda under the trade name zyloprim. It is a xanthine oxidase inhibitor which is administered orally. From the experts at healthnotes, this revised and updated edition contains the newest information on thousands of drugs and supplements, based on studies published in the leading medical journals. Allopurinol oral zyloprim side effects, medical uses. When a patient is taking medications, there is potential for interaction that may put nutrient balance out of order. Supplement vitamin d and calcium when drug is used for 1 month. Subsequent adjustment of doses of mercaptopurine or azathioprine should be. Food drug interactions is a broader term that describes the effects of a drug on nutritional status. Important drugmicronutrient interactions to know pharmacy times. Interaction of allopurinol and hydrochlorothiazide during. Look up a drug to see which other drugs it interacts with and how serious those interactions are.
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